Sandra "Sandy" Cheeks is a squirrel from Texas who loves Karate and Science. She lives in a Treedome and has to wear a space suit and helmet to survive and walk underwater
SpongeBob SquarePants- SpongeBob was the first character to interact with Sandra and interacts the most. They are friends.
Patrick Star - Patrick usually acts stupid around and she sometimes gets mad. They are Partial Friends
Squidward Tentacles - Even though Sandy attacked Squidward in "Sportz?," they are possible love interests. Sandy called Squidward "Squid Cakes" in "Whatever Happened To SpongeBob" and cared for him when he got a reed stuck in his throat. They are friends (and hinted love interests).